Sitting Disease
日本語
On average people spend most of their waking life sitting down, which is associated with an increased risk of death even among those who go to the gym after work and exercise regularly. Sitting 6 hours or more and not doing much of anything may double our risk of diabetes and heart disease and significantly shorten our lifespan, even at the highest levels of physical activity. Why though?
One factor may be endothelial dysfunction, the inability of the inner lining of our blood vessels to relax our arteries normally in response to blood flow. Just like our muscles atrophy if we don’t use them, when it comes to arterial function it’s a use it or lose it as well.
Increased blood flow promotes a healthy endothelium. The cells lining of our arteries can actually sense the sheer force of the blood flowing past. That flow is what maintains the stability and integrity of the inner lining of our arteries. Without that constant tugging flow, it may help set up for heart disease.
What if sitting all day is part of our job, though? You can use a standing or walking treadmill desk and walking may be preferable to standing, in terms of clearing fat from our bloodstream, which can play a role in endothelial dysfunction.
What if our office can’t accommodate a standing or walking desk? Within an hour of sitting, blood flow starts to stagnate, so regular interruptions in sitting time can be beneficial, and it doesn't have to be long.
Breaks could be as short as 1 minute and not necessarily entail "Exercise", just like taking out the trash, go to kitchen and make a tea or something, can be beneficial. What if we have a job where we’re sitting down and can’t take frequent breaks, like truck driving? Is there any way to improve our endothelial function sitting on our butts?
One factor may be endothelial dysfunction, the inability of the inner lining of our blood vessels to relax our arteries normally in response to blood flow. Just like our muscles atrophy if we don’t use them, when it comes to arterial function it’s a use it or lose it as well.
Increased blood flow promotes a healthy endothelium. The cells lining of our arteries can actually sense the sheer force of the blood flowing past. That flow is what maintains the stability and integrity of the inner lining of our arteries. Without that constant tugging flow, it may help set up for heart disease.
What if sitting all day is part of our job, though? You can use a standing or walking treadmill desk and walking may be preferable to standing, in terms of clearing fat from our bloodstream, which can play a role in endothelial dysfunction.
What if our office can’t accommodate a standing or walking desk? Within an hour of sitting, blood flow starts to stagnate, so regular interruptions in sitting time can be beneficial, and it doesn't have to be long.
Breaks could be as short as 1 minute and not necessarily entail "Exercise", just like taking out the trash, go to kitchen and make a tea or something, can be beneficial. What if we have a job where we’re sitting down and can’t take frequent breaks, like truck driving? Is there any way to improve our endothelial function sitting on our butts?
Turmeric-Curcumin vs. Exercise For Artery Function
Well, lifestyle modification is a desirable way to prevent or treat endothelial dysfunction without the need for drugs. First we need to get rid of our butts.
Smoking a single cigarette can significantly impair endothelial function. Including certain foods in our diet like Walnut, Green Tea and in particular Curcumin the yellow pigment in the spice Turmeric is beneficial.
Smoking a single cigarette can significantly impair endothelial function. Including certain foods in our diet like Walnut, Green Tea and in particular Curcumin the yellow pigment in the spice Turmeric is beneficial.
Regular ingestion of Curcumin or up to an hour a day of Aerobic Exercise Training significantly improves endothelial function, and the magnitude of improvement in endothelial function is the same.
The combination of Curcumin and exercise may work even better, than either alone.
The combination of Curcumin and exercise may work even better, than either alone.
Sources
http://nutritionfacts.org/
N Akazawa, Y Choi, A Miyaki, Y Tanabe, J Sugawara, R Ajisaka, S Maeda. Curcumin ingestion and exercise training improve vascular endothelial function in postmenopausal women. Nutr Res. 2012 Oct;32(10):795-9.
J Sugawara, N Akazawa, A Miyaki, Y Choi, Y Tanabe, T Imai, S Maeda. Effect of endurance exercise training and curcumin intake on central arterial hemodynamics in postmenopausal women: pilot study. Am J Hypertens. 2012 Jun;25(6):651-6.
E Shvartz, J G Guame, R T White, R C Reibold. Hemodynamic responses during prolonged sitting. J Appl Physiol Respir Environ Exerc Physiol. 1983 Jun;54(6):1673-80.
S S Thosar, B D Johnson, J D Johnston, J P Wallace. Sitting and endothelial dysfunction: the role of shear stress. Med Sci Monit. 2012 Dec;18(12):RA173-80.
N Owen, G N Healy, C E Matthews, D W Dunstan. Too Much Sitting: The Population-Health Science of Sedentary Behavior. Exerc Sport Sci Rev. Jul 2010; 38(3): 105–113.
M C Peddie, J L Bone, N J Rehrer, C M Skeaff, A R Gray, T L Perry. Breaking prolonged sitting reduces postprandial glycemia i n healthy, normal-weight adults: a randomized crossover trial. Am J Clin Nutr. 2013 Aug;98(2):358-66.
E G Wilmot, CL Edwardson, F A Ahana, M J Davies, T Gorely, L J Gray, K Khunti, T Yates, S J Biddle. Sedentary time in adults and the association with diabetes, cardiovascular disease and death: systematic review and meta-analysis. Diabetologia. 2012 Nov;55(11):2895-905.
A V Patel, L Bernstein, A Deka, H S Feigelson, P T Campbell, S M Gapstur, G A Colditz, M J Thun. Leisure time spent sitting in relation to total mortality in a prospective cohort of US adults. Am J Epidemiol. 2010 Aug 15;172(4):419-29.
M Miyashita, J H Park, M Takahashi, K Suzuki, D Stensel, Y Nakamura. Postprandial lipaemia: effects of sitting, standing and walking in healthy normolipidaemic humans. Int J Sports Med. 2013 Jan;34(1):21-7.
G A Koepp, C U Manohar, S K McCrady-Spitzer, A Ben-Ner, D J Harnann, C F Runge, J A Levine.. Treadmill desks: A 1-year prospective trial. Obesity (Silver Spring). 2013 Apr;21(4):705-11.
G N Healy, C E Matthews, D W Dunstan, E A Winkler, N Owen. Sedentary time and cardio-metabolic biomarkers in US adults: NHANES 2003-06. Eur Heart J. 2011 Mar;32(5):590-7.
G N Healy D W Dunstan, J Salmon, E Cerin, J E Shaw, P Z Zimmet, N Owen. Breaks in sedentary time: beneficial associations with metabolic risk. Diabetes Care. 2008 Apr;31(4):661-6.
N Akazawa, Y Choi, A Miyaki, Y Tanabe, J Sugawara, R Ajisaka, S Maeda. Curcumin ingestion and exercise training improve vascular endothelial function in postmenopausal women. Nutr Res. 2012 Oct;32(10):795-9.
J Sugawara, N Akazawa, A Miyaki, Y Choi, Y Tanabe, T Imai, S Maeda. Effect of endurance exercise training and curcumin intake on central arterial hemodynamics in postmenopausal women: pilot study. Am J Hypertens. 2012 Jun;25(6):651-6.
E Shvartz, J G Guame, R T White, R C Reibold. Hemodynamic responses during prolonged sitting. J Appl Physiol Respir Environ Exerc Physiol. 1983 Jun;54(6):1673-80.
S S Thosar, B D Johnson, J D Johnston, J P Wallace. Sitting and endothelial dysfunction: the role of shear stress. Med Sci Monit. 2012 Dec;18(12):RA173-80.
N Owen, G N Healy, C E Matthews, D W Dunstan. Too Much Sitting: The Population-Health Science of Sedentary Behavior. Exerc Sport Sci Rev. Jul 2010; 38(3): 105–113.
M C Peddie, J L Bone, N J Rehrer, C M Skeaff, A R Gray, T L Perry. Breaking prolonged sitting reduces postprandial glycemia i n healthy, normal-weight adults: a randomized crossover trial. Am J Clin Nutr. 2013 Aug;98(2):358-66.
E G Wilmot, CL Edwardson, F A Ahana, M J Davies, T Gorely, L J Gray, K Khunti, T Yates, S J Biddle. Sedentary time in adults and the association with diabetes, cardiovascular disease and death: systematic review and meta-analysis. Diabetologia. 2012 Nov;55(11):2895-905.
A V Patel, L Bernstein, A Deka, H S Feigelson, P T Campbell, S M Gapstur, G A Colditz, M J Thun. Leisure time spent sitting in relation to total mortality in a prospective cohort of US adults. Am J Epidemiol. 2010 Aug 15;172(4):419-29.
M Miyashita, J H Park, M Takahashi, K Suzuki, D Stensel, Y Nakamura. Postprandial lipaemia: effects of sitting, standing and walking in healthy normolipidaemic humans. Int J Sports Med. 2013 Jan;34(1):21-7.
G A Koepp, C U Manohar, S K McCrady-Spitzer, A Ben-Ner, D J Harnann, C F Runge, J A Levine.. Treadmill desks: A 1-year prospective trial. Obesity (Silver Spring). 2013 Apr;21(4):705-11.
G N Healy, C E Matthews, D W Dunstan, E A Winkler, N Owen. Sedentary time and cardio-metabolic biomarkers in US adults: NHANES 2003-06. Eur Heart J. 2011 Mar;32(5):590-7.
G N Healy D W Dunstan, J Salmon, E Cerin, J E Shaw, P Z Zimmet, N Owen. Breaks in sedentary time: beneficial associations with metabolic risk. Diabetes Care. 2008 Apr;31(4):661-6.